Epistasis and Genetic Regulation of Variation in the Arabidopsis Metabolome
نویسنده
چکیده
منابع مشابه
Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome.
Genomic approaches have accelerated the study of the quantitative genetics that underlie phenotypic variation. These approaches associate genome-scale analyses such as transcript profiling with targeted phenotypes such as measurements of specific metabolites. Additionally, these approaches can help identify uncharacterized networks or pathways. However, little is known about the genomic archite...
متن کاملBiochemical Networks and Epistasis Shape the Plant Metabolome
Genomic approaches have accelerated the study of quantitative genetics underlying phenotypic variation. These approaches associate genome-scale analyses such as transcript profiling with targeted phenotypes such as measurements of specific metabolites. Additionally, these approaches have potential utility in identifying uncharacterized networks/pathways. However, little is known about the compl...
متن کاملCytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome
Understanding genome to phenotype linkages has been greatly enabled by genomic sequencing. However, most genome analysis is typically confined to the nuclear genome. We conducted a metabolomic QTL analysis on a reciprocal RIL population structured to examine how variation in the organelle genomes affects phenotypic variation. This showed that the cytoplasmic variation had effects similar to, if...
متن کاملThe metabolic background is a global player in <italic>Saccharomyces</italic> gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype–phenotype relationship. The metabolic–genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metabolic–genetic background by monitoring transcriptome, proteome and metabolome in a repertoire of 16 S...
متن کاملGenetic Networks Controlling Structural Outcome of Glucosinolate Activation across Development
Most phenotypic variation present in natural populations is under polygenic control, largely determined by genetic variation at quantitative trait loci (QTLs). These genetic loci frequently interact with the environment, development, and each other, yet the importance of these interactions on the underlying genetic architecture of quantitative traits is not well characterized. To better study h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008